The three receptors targeted by retatrutide are GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors
GIP receptor activation may contribute to improved metabolic function, while GLP-1 receptor agonism primarily mediates appetite suppression through central nervous system pathways affecting satiety centers in the hypothalamus
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Most patients lose 3-8 pounds in the first 4 weeks, though some see minimal scale changes while experiencing significant appetite reduction and body composition shifts
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