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Silencing of miR122 has been shown to upregulate CAT-1 ( SLC7A1 ) expression, and subsequently increase arginine uptake to maintain large intracellular arginine pools for nitric oxide (NO) synthesis, resulting in increased resistance to the multi-kinase inhibitor sorafenib (Kishikawa et al., 2015)

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One of the problems that have emerged, especially when many of these drugs have been tested in vitro for their inhibition properties, is their lack of specificity

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