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Zu ROS zhlen unter anderem freie Radikale und Wasserstoffperoxid

Although an inverse relationship between blood HDL-C concentration and the risk of cardiovascular events has been demonstrated repeatedly, studies concerning agents increasing its concentration (i.e., niacin or cholesterol ester transfer protein (CETP) inhibitors) have not yet demonstrated their beneficial effects in terms of cardiovascular risk reduction [77, 78]

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The distribution might also cross certain zones and may manifest as bridging necrosis showing confluence of the lesions (e.g., central to central veins, portal tract to portal tract, or portal tract to central zones)