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371 have reported that ADA3 is over expressed in breast cancer patients and as a transcriptional co-activator, human ADA3 (hADA3) interacts with ER, thereby transactivating its downstream targets leading to breast cancer progression

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5.1 Signaling mechanisms from the gut microbiota to the brain SCFAs, BAs, and other metabolites have been implicated as signaling molecules mediating host-microbe communication via EECs and ECCs by acting on the corresponding receptors, which can regulate many CNS activities, including energy and glucose metabolism as well as HPA activity (400404)

Other competitors, including Pfizer, AstraZeneca, and Roche, are developing oral or non-peptidic GLP-1 alternatives