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Role of Growth Factors Growth factors such as epidermal growth factor receptor (EGFR) ligands and hepatocyte growth factor (HGF) are considered primary mitogens (which can directly stimulate hepatocyte proliferation even in serum-free media or in vivo stand-alone) for hepatocytes, and are crucial for liver regeneration after PH and maintaining liver homeostasis.22, 29, 30 In fact, EGFR ligands [eg, EGF and transforming growth factor (TGF)-] and HGF are the only known primary mitogens for hepatocytes