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It has been previously shown that 4-keto-VPA causes abnormal and irregular growth of the neural tube neuroepithelium, microvesicular steatosis, and reduces ammonia excretion through inhibition of carbamoyl phosphate [114], which significantly increases the risk of VPA-induced ADRs, including teratogenesis

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The likelihood of kidney damage increases with higher doses of these medications

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Many UMR-administered plans offer coverage for FDA-approved weight loss drugs, but with strict criteria and prior authorization requirements