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Participants were classified as having any SUD if they met criteria for one or more of these individual conditions

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Widespread scars Also known as stretched scars, widespread scars are common after surgery

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Continuous monitoring of clinically significant biomarkers, such as small molecules [76, 77], glucose [78,79,80,81], lactate [82, 83], cholesterol [84], inflammatory cytokines (such IL-6) [87], reactive oxygen species [85, 86]), and nucleic acids [87,88,89,90], has also been greatly facilitated by wearable microneedle diagnostics that employ biosensing nanoparticles