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One of the most important risk factors for glaucoma is elevated intraocular pressure (IOP), which promotes mechanical stress in RGCs and the lamina cribrosa, blockading axonal transport and causing axonal degeneration 3,4

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The AlphaFold2 analysis also recreates the intersection of the Lasso motif, R-domain, and the loop following TMD0 observed in our structures

Antigens bind to the target cells through their antigen binding fragment (Fab), while the interaction with the effector cells occurs between the fragment crystallizable region (Fc) portion of the antibody (168)