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Cancer Res 69(6):25062513 Adotevi O et al (2010) A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients

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46 injected in vitro-synthesized mRNA into mouse skeletal muscle and successfully induced the expression of specific proteins

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In its SMAD pathway, TGF- binds to type II receptors, leading to the phosphorylation of downstream R-SMADs (R-SMAD2 and R-SMAD3) (Jones et al., 2009)