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You might experience side effects when you start taking the medication and when you increase your dose

Shantsila E et al (2020) Spironolactone in atrial fibrillation with preserved cardiac fraction: the IMPRESS-AF trial, (in eng)

H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation

Different tolerability issues: Both can cause gastrointestinal symptoms, but the risk patterns differ