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With the exception of interactions of Glu1 and Asp3 with polar residues deep in the bundle, the first 9 residues of exendin-P5 do not form stable interactions with the TMD

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Environ Health Perspect.,2001,109 (2):259-266.,VossKA,RileyRT,NorredWP,BaconCW,MeredithFI,HowardPC,PlattnerRD, Hansen DK,Porter JKCollinsTF 110

Changes from baseline in SBP and DBP were prespecified key secondary and secondary endpoints of SURMOUNT-1, respectively

In the phase 2 trial, participants started at 4 mg without escalation experienced significantly more adverse events than those who began at 2 mg

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