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Importantly, it does not significantly stimulate ACTH, cortisol, or prolactin release at physiological doses (PMID: 9849822)

Kriisa, K., Haring, L., Vasar, E., Koido, K., Janno, S., Vasar, V., Zilmer, K., & Zilmer, M

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The expectation that incretin therapy may not only improve -cell function but also increase -cell mass in patients with type 2 diabetes mellitus was not substantiated, in marked contrast to findings in rodents [12]

The dermal layer relies on collagen type I and III to maintain bounce and firmness, and these proteins naturally decline with age and during caloric restriction