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To determine whether glutathione imbalances were capable of sensitizing hepatocytes to TNF-induced cell death, hepatocytes were pretreated with H 2 O 2 (0.1 and 0.2 mM) for 2 h, followed by TNF addition (40 ng/mL)

Uncontrolled levels of oxidative stress may lead to inflammation, accelerate aging and facilitate the development of chronic conditions

Willoughby DS, Stout JR, Wilborn CD

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