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Genetic variants can impact how well you produce glutathione and detoxify certain toxicants

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Protein kinase C type isoform 2 (PKCII) is able to recognize the initial lipid peroxidation, promote the phosphorylation of ACSL4 on Thr328 to activate phospho-ACSL4, and facilitate the incorporation of PUFA into PLs, leading to the termination of the cells (9)