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Supplements provide a concentrated, bioavailable dose that food alone often cannot match

Older adults often notice larger, more frequent bruises from minor knocks that would not have caused a bruise when they were younger

This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

The recommended daily intake for adults in the UK is 1.5 micrograms, with a slight increase recommended during breastfeeding, but not during pregnancy

[1] Other manifestations of B12 deficiency include glossitis (sore, red tongue), mouth ulcers, visual disturbances, and in severe cases, psychiatric symptoms such as depression, psychosis, or dementia-like presentations

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