Hepatic encephalopathy (HE) is a significant cause of morbidity and mortality in advanced cirrhotic patients [58]
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Notably, pDCs are the major producers of IFN- in SLE, and IFN- production from pDC mediated by TLR9 is reduced by mTOR inhibitor, which regulates pDC differentiation and activation by modulating mitochondrial biogenesis and energy metabolism (78)
Adverse neuropsychiatric effects of antimalarial drugs
Additionally, some novel GLP-1s hold promise for improved tolerability, as evidenced by Structure Therapeutics phase 2 data for GSBR-1290, which demonstrated encouraging results in terms of AEs and discontinuation rates