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[3] Dosing follows a monthly escalation schedule designed to minimize GI side effects: 0.8 mg 2.5 mg 5.5 mg 9 mg 14.5 mg 17.2 mg, with the target maintenance dose reached after about six months

What we know: The same total amount reaches your bloodstream - Clinical trial data confirmed equivalent overall absorption (AUC and Cmax) across all three sites Yet reported side effect rates differed substantially - Thigh showed roughly half the nausea rate of abdomen despite identical systemic exposure Possible explanations include differences in absorption rate (even if total absorption is equal), local tissue effects at the injection site, or simply statistical variation in a relatively small study

Immunity 30 , 899911 (2009)

According to the PIONEER 3 trial, Rybelsus 3 mg reduced weight by an average of 0.6 kg at week 26