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In a PD model, the combination of palmitoylethanolamide with luteolin has been shown to reduce neuroinflammation and promote autophagy (Cordaro et al

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A study using EndoC-H1 cells found that IFN treatment leads to inflammation, ER stress, and an increased expression of HLA class I proteins

Non-steroidal anti-inflammatory drugs (NSAIDs), statins, glucocorticoids and monoclonal antibodies (e.g., targeting IL-6, TNF-, IL-12/23) have been reported to show moderate anti-depressant capacity in patients with somatic disorders (i.e., rheumatoid arthritis, psoriasis) who also had comorbid symptoms of depression [194, 195]

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