glp-1 shits Insurance coverage just changed for as many as 56 million Americans when it comes to the popular medications used to promote weight loss. link in bio 🔗 I'm a dietitian — but

The inhibitory effect is presumably mediated indirectly through somatostatin secretion, but a direct effect cannot be completely excluded

Multiple neuropsychiatric drugs, including bupropion, quetiapine, and aripiprazole, were included among these medications

The key findings are eye-opening: First month off: Weight loss continues briefly (~4 weeks)

Theyre not going to have the same effects as drugs such as Ozempic, which stay in the body at a lot higher levels. Notably, semaglutide drugswhich mimic GLP-1bind to GLP-1 receptors and activate them but have a much longer duration of action due to their structural modifications, which make them less susceptible to enzymatic degradation, he points out

BMC Nutr

10.1038/nature00887 5 BistG.ElsheikhA.KimS.HuangR.Y.RuszajD.WooS.et al (2012)