revealed that overexpression of ZIP6 or elevated intracellular zinc levels in cancer cells substantially activated the PI3K/AKT and MAPK/ERK signaling, which upregulated downstream oncogenes such as MMP1 , MMP3 , MYC , and SLUG
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10.1681/ASN.0000000000000195 7 ChenW.GuoL
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Increased intracellular FFAs activate a range of gene families involved in the functional regulation of the endoplasmic reticulum, crucial for LD formation and lipid storage dynamics [97]