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The gut microbiota may be interacting with the other pathways such as inflammation, or endocrine which then interact with and affect the integrity of the BBB, but either way it is now apparent that the gut microbiota is a modulator of BBB integrity

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if it persists, the prescriber may consider an unpreserved single-dose preparation, accepting the shorter beyond-use window

Key findings of the paper: Finding 1: NNMT is highly expressed in adipose tissue