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Furthermore, intracellular Fe 2+ is pumped into the extracellular space through membrane ferritin 1 (SLC40A1/FPN1) to strictly maintain cellular iron homeostasis ( Many studies have demonstrated that iron metabolism-related proteins could be used as targets to regulate ferroptosis

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Nutritional Status and Iron Levels: A well-known effect of GLP-1s is appetite suppression

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The disruption of the outer blood-retinal barrier observed in DR patients and diabetic mouse models [62] can activate RPE cells, triggering the EMT process

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