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The exact mechanism remains unclear, but vascular changes or rapid metabolic shifts may contribute

Across all reviews, there was little or no difference between these medications and placebo regarding serious cardiovascular events, quality of life, or mortality

Many patients do very well with standard once-weekly dosing

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For example, administration of -MSH directly into the brain inhibits the acute inflammation caused by picryl chloride [46], blocks the immunosuppressive effect of central IL-1 administration [47], and reduces systemic inflammation in endotoxemic mice [48]

Safety and tolerability outcomes comprised discontinuation of treatment due to adverse events, incidence of serious adverse events, all-cause mortality, hypoglycaemia (plasma glucose 3.9 mmol/l), severe hypoglycaemia (a hypoglycaemic event requiring assistance), nausea, vomiting and diarrhoea