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GIP receptor activation in the brain may contribute to appetite regulation through mechanisms distinct from GLP-1 signaling, potentially explaining tirzepatide's superior weight loss compared to GLP-1 monoagonists

Also, recent advances in molecular imaging have been useful in monitoring changes of pancreatic -cells, playing a significant role in diagnosing the disease and evaluating effectiveness of therapeutic interventions and islet transplantation

Metabolic syndrome is a cluster of conditions related to cardiovascular disease and type 2 diabetes risk, comprising abdominal obesity, elevated blood sugar and triglyceride levels, high blood pressure, and low HDL-cholesterol level

Their use presents safety considerations that require careful consideration

[DOI] [PubMed] [Google Scholar] Mller-Moul P, Conklin PL, Niyogi KK

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