GLP-1s were associated with lower risk of complications for those already having a substance use disorder Among people who already had a substance use disorder, starting a GLP-1 medication was associated with fewer substance-related emergency department visits, hospital admissions, overdose events, episodes of suicidal ideation or attempts, and lower mortality (see graph below)
Budzynska B, Wnorowski A, Kaszubska K, Biala G, Kruk-Somka M, Kurzepa J, Boguszewska-Czubara A (2018) Acute MDMA and nicotine co-administration: behavioral effects and oxidative stress processes in mice
Data from the SURMOUNT trials showed that participants losing significant weight on tirzepatide experienced approximately 33-39% of total weight loss from lean body mass
GHRP-2 shows appetite stimulation too, but weaker and less consistent
Neurological recovery may take months and can be incomplete if deficiency is prolonged
The accumulation of such organelle stress ultimately contributes to diverse disease phenotypes, ranging from neurodegeneration and metabolic disorders to cancer progression, immune dysregulation and tissue aging
