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Those effectsreduced appetite, slower stomach-emptying and unexpected weight lossled the U } The Risks of Microdosing GLP-1s GLP-1 medications are powerful, but theyre not benign

However, these medications are not set-and-forget solutions

Therefore, therapeutic principles acting via different receptors and postreceptor pathways seem attractive in view of potentially additive or synergistic effects

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Questions around long-term safety, optimal dosing, patient selection, and how such combinations might eventually be sequenced into routine prescribing remain open.5 But the direction of travel is unmistakable, and it represents a meaningful shift from where the conversation stood even twelve months ago