Without intrinsic factor, vitamin B12 absorption is significantly impaired, which is why vitamin B12 deficiency is more common in individuals with gastrointestinal disorders that affect intrinsic factor production or absorption
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These mechanisms combined produce effects comparable to those of amphetamines: lessened hunger, heightened alertness, and mild euphoria, accompanied by elevations in blood pressure and heart rate
However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics
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