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Clinically, motilin receptors have become therapeutic targets for prokinetic agents, particularly motilides such as erythromycin, though long-term efficacy is limited by receptor desensitization

Increased inhibition is marked by a higher "+" designation

GHK-Cu acts as a copper-binding signalling peptide that modulates the expression of thousands of genes involved in collagen remodelling, antioxidant defence, and tissue repair

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The role of conformational dynamics and allostery in modulating protein evolution

The identification of selenium-independent isoforms, such as GPx7, has broadened our understanding of the familys functional diversity and suggests the existence of additional regulatory mechanisms beyond classical selenium-dependent catalysis