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Often, appendicitis is probably the result of an obstruction of the area inside the appendix called the appendiceal lumen (the interior of the tube of the appendix), or appendix lumen

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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Dikeocha I.J., Al-Kabsi A.M., Miftahussurur M., Alshawsh M.A

for others, it may subtly influence hunger cues or side effects

Cold Spring Harb Perspect Med 8:a030361