Once the sarcopenia and the wasting start and the metabolic dysfunction and the insulin resistance start rolling, it drives the inflammation
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Factor #2: PCOS improvement happens faster than expected For women with PCOS, GLP-1s create a perfect storm of fertility improvement through improved insulin sensitivity (which is often the root problem in PCOS), reduced androgen levels as testosterone and other androgens drop when insulin improves, ongoing weight loss effects where each pound lost further improves hormonal balance, and potentially direct ovarian effects as some evidence suggests GLP-1s may directly improve ovarian function
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Oral semaglutide and liraglutide, notably, show little to no lean mass loss
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