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We found that after eight weeks of TAC, the levels of cardiac glycolysis-related metabolites (glucose 6-P, fructose 6-P, 3-PG, PEP, and pyruvate), the pentose phosphate pathway (PPP) (glucose-1-P, 6-PG, and ribose-5-P) and lipids (stearic acid et al) were significantly increased, but the amount of pyruvate entering the TCA cycle (citrate and aconitate) was reduced (Fig