Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate
Rather than diet or oral supplements , an overdose of B12 is majorly caused due to high doses of injection, said (Ms) Roshan Kore, senior dietitian and nutritionist, SRCC Childrens Hospital, managed by Narayana Health (Haji Ali, Mumbai)
PMC 2035923
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