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A complicating factor in clinical trials has been the significant inter-individual variability in susceptibility to APAP toxicity 14

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Remarkably, inhibition of CD40-TRAF6 signaling reversed the secretion of these mediators, suggesting that targeting this pathway may offer therapeutic benefit (207)

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Tilley, S

Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways