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As such, GIP analogs were initially not pursued as monotherapies to treat diabetes or obesity due to the perception of an overall weak biological effect, in part because of early findings suggesting a GIP resistance in the diabetic condition (21) alongside incongruent results on its hypophagic and body weightlowering effects (19,2226)

Ongoing monitoring typically involves monthly or quarterly check-ins during dose titration, regular assessment of weight loss progress and tolerability, periodic lab work to monitor metabolic parameters, and screening for potential complications

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Injection of IL-6 in healthy subjects leads to activation of the HPA system, increased cortisol production, breakdown of fat stores, and greater energy expenditure