Here's what to expect: Typical Semaglutide Titration: Weeks 1-4: 0.25 mg weekly (lowest dose) Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Weeks 13-16: 1.7 mg weekly Week 17+: 2.4 mg weekly (maintenance) Typical Tirzepatide Titration: Weeks 1-4: 2.5 mg weekly Weeks 5-8: 5 mg weekly Weeks 9-12: 7.5 mg weekly Weeks 13-16: 10 mg weekly Weeks 17-20: 12.5 mg weekly Week 21+: 15 mg weekly (maintenance) You'll have a nurse check-in at each dose adjustment to monitor tolerability, appetite suppression, weight change, and side effects
The clinical trial sponsors include foreign giants such as Eli Lilly, AstraZeneca, and MSD, as well as Chinese domestic companies, e.g., Hengrui Pharmaceuticals, Gan & Lee, and Tonghua Dongbao
Within the practice, GLP-1 therapy sits alongside the rest of the medical weight loss toolkit: structured nutrition, the non-GLP-1 weight loss medications for patients who are not candidates or who need adjuncts, and the foundational framing of obesity as a disease
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PMID 24742660
besides this, shortages and supply chain difficulties by pharma companies with constrained production capacity and a risk of counterfeit products in the market
