B12 and related B vitamins are worth special attention because many compounded GLP-1 formulations include B12 with semaglutide or B12 with tirzepatide precisely because reduced food intake lowers B vitamin status
While alcohol use on a GLP-1 may be okay, the choice carries some theoretical risks, including reduced weight loss potential and possibly worsened side effects of GLP-1s
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In the Phase 2 trial, 72% of participants who had prediabetes at the start had normal glycated hemoglobin levels at 48 weeks, compared to just 22% on placebo
Therefore, GLP-1 should not induce hypoglycemia when administered alone or with other antidiabetic agents that do not cause hypoglycemia, such as metformin (MET), thiazolidinediones (TZDs) and alpha-glucosidase inhibitors (AGIs)
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