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Certain proteins and peptides cross intestinal epithelium through transcytosis and other transport mechanisms

In goblet cells, elevated MUC2 mucin expression and misfolding lead to ER stress, triggering reactive oxygen species production and apoptosis, ultimately disrupting the integrity of the mucus barrier [90]

Plasma half-life estimates range from 30-60 minutes based on limited animal and human studies, though systematic pharmacokinetic characterization in humans has not been published

But it lacks the comprehensive metabolic remodeling you get from simultaneous GLP-1/GIP/glucagon activation

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