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GPx4, abundant in the brain, is particularly implicated

2A, compared with VRK2-KO cells downregulating the paralog genes involved in the GSH metabolic pathway, VRK2-KO cells with GCLC, GSS, and especially SLC7A11 knockdown exhibited increased ROS level, decreased GSH level and cellular viability

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Because of this and the fact that the body only needs a small amount of vitamin B12 each day, it can take up to a year or even longer for an inadequate vitamin B12 to manifest as an apparent deficiency

[PubMed: 15486212] [CrossRef] 173