In an oncogenic context, the IGF family regulates a number of biological processes such as cancer cell proliferation, apoptosis, metabolism and protein synthesis, which are closely associated with the activation of PI3K/AKT signaling, which subsequently promotes the transcription of downstream pro-oncogenic target genes such as c-Myc and HIF-1 (77)
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cmh-2022-0330-Supplementary-9.pdf Figure 1
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[8] The age-related decline and its implications The decline of circulating GHK from 200 ng/mL at age 20 to 80 ng/mL by age 60 correlates with reduced wound healing capacity, thinner skin, decreased collagen density, and slower tissue repair