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In animal and in-vitro research it has been investigated for effects on tendon, ligament, muscle, and gut-tissue repair, where it appears to promote angiogenesis (new blood-vessel formation) and accelerate cellular healing

Liver enlargement may also occur secondarily to exposure to hemolytic or nephrotoxic xenobiotics (Glaister 1986

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In hTYR, Although CME is a shorter tripeptide, it can pull the loop regions towards the pocket center, narrowing and occupying the pocket entrance

For this purpose, activation of adaptive stress responses was investigated for DNA damage (p21), oxidative stress (SRXN1), inflammation (ICAMI), and ER stress (CHOP) using a HepG2-based GFP-reporter assay (Wink et al., 2014, 2017)