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The titration schedule exists to protect you from side effects that make treatment unsustainable

There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]

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Rob Berberian or another qualified physician regarding any medical condition, medication, or procedure, including GLP-1 receptor agonist therapy

That means patients may not always know what they are getting, he added

16-18 Nausea is the most frequently reported AE among GLP-1 RAs, with rates ranging from 20% to 40% depending on the agent and dose