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Information from each article was extracted into tables, including country, year of publication, authors, number of patients, study type, potential biomarker, and the technique used for its evaluation, as well as the type of association, outcome, effect measure, and/or p-value

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It can also stimulate the secretion of the mucous that makes up part of the protective layer of the mucous membrane and help restore tight junction proteins, which can be lost in conditions such as inflammatory bowel disease (IBD) and celiac disease

These actions modulate physiological processes and contribute to methylene blues therapeutic effects in conditions like methemoglobinemia and neuroprotection

Aging 1 , 870879 (2021)