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As with most drugs, the potential benefits of semaglutide come with certain risks

According to Rome III, constipation symptoms for at least six months along with two or more of the following criteria for at least three months constitutes chronic constipation (Leung, Riutta 2011

Large-scale human trials are lacking, and it is not approved for any therapeutic purpose

Furthermore, the effectiveness of Ozempic in weight loss has been primarily studied over longer than six weeks, with the best results seen in conjunction with a reduced-calorie diet and increased physical activity

Mol Cancer Ther 2008

Less common but more severe effects include pancreatitis and bowel obstruction