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In a mouse model of diabetes, topiramate effectively protected the brain from diabetes-induced damage by reducing 4-HNE levels and increasing glutathione (GSH) levels (Price et al., 2015)

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Mikus, N., Marszaek, K., Podlacha, M., et al

In clinical trials, semaglutide has demonstrated robust reductions in hemoglobin A1c (HbA1c), with mean decreases ranging from 1.0% to 1.8% depending on the dose and patient population

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