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This prevents ROS-dependent assembly of the NLRP3 inflammasome and caspase-1mediated cleavage of pro-IL-1 and pro-IL-18, blocking the amplification of inflammatory signaling

Importantly, their Mn III centers are fixed in the N 4 -macroheterocycles and axially ligated with two water molecules, such coordination environments are geometrically analogous to those of the active metal sites of Mn-SOD and catalase, making this category of molecules feature both SOD- and catalase-like activities 6,7

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