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Interestingly, while Ex4(2-39) retains high affinity and full activity at 10 nM, the replacement of Asp 9 with Glu resulted in the complete loss of efficacy, despite no effect upon affinity (Montrose-Rafizadeh et al ., 1997), suggesting that Asp 9 plays an important role in activity

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County-level tables reflect the most recent year of available data