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Light exposure is a secondary but real concern: ultraviolet light can break down aromatic amino acid residues over time, which is why storing vials in their original container, away from direct light, is standard practice rather than an optional precaution

Histological analysis reveals that aged kidneys accumulate senescent cells primarily in tubular regions, identified by loss of Lamin B1 (LMNB1), elevated senescence-associated -galactosidase activity, and expression of inflammatory IL-6

doi: 10.3389/fphar.2022.819728 182 ZhuY.XiongY.GuY.LiQ.LiuY

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All experiments were repeated three times independently with consistent results, and representative data are shown