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Pregnancy and lactation represent additional contraindications due to the absence of safety data in these populations

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259 A double-blind placebo-controlled trial randomized 56 healthy individuals aged 2565 years with borderline cardiovascular disease (CVD) risk factors to receive placebo or 500 mg aged black garlic (providing 2.5 mg SAC) for 12 weeks

There is currently no strong evidence showing that BPC-157 significantly increases metabolism

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508 , 729 , 730 In 2019 and again in 2025, the National Institute on Aging (NIA) awarded funding to create the NIA Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory