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10.1007/s00109-016-1488-y [DOI] [PubMed] [Google Scholar] Huang T., Zhang K., Sun L., Xue X., Zhang C., Shu Z., et al

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This impairment of DNA synthesis affects the rapidly dividing cells of the bone marrow earlier than other cells, resulting in the production of large, immature, hemoglobin-poor red blood cells (macrocytosis), as well as effects on white blood cells, including abnormal (hypersegmented) neutrophils and reduced overall cell counts (pancytopenia)

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