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Lentivirus containing shRNA targeting either a non-specific scramble sequence (sh-C) or specifically targeting NRF2 (sh-NRF2-a and sh-NRF2-b) was used to transduce HaCaT cells

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Treating cells with cumene hydroperoxide was shown to enhance eryptosis, whereas the antioxidant NAC mitigated this process by enhancing RBC deformability and reducing levels of ROS, calcium, and PS exposure, and demonstrated that oxidative stress plays a crucial role in eryptosis, with pro-oxidants promoting and antioxidants limiting eryptotic processes [413]

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Aftercare Guidance We provide instructions on hydration, diet, and skincare to enhance results